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. 2013 Sep 18;23(2):514–523. doi: 10.1093/hmg/ddt452

Figure 2.

Figure 2.

Improved photoreceptor survival after AAV2/8(Y733F)-Rho-Pde6α transduction at mid-stage of disease. H&E stained retinal section of an untreated Pde6αD670G mouse retina (A), the fellow P21-treated Pde6αD670G mouse retina (B), a P5-treated Pde6αD670G mouse retina (C) and B6 control mouse (D) at 6 months of age. Scale bar: 600 µm. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; IS, inner segments; OS, outer segments; RPE, retinal pigment epithelium. Quantification of the thickness of the ONL by counting the columns of photoreceptor nuclei in the rescued half of the treated retina, the un-rescued half of the treated retina (labeled internal control) and fellow-untreated eyes from 3 to 6 months of age (E). Error bars show SEM for each time-point and the significance was calculated for the rescued half of the P21-treated retina compared with the untreated fellow eyes using paired t-test analysis. N ≥ 3 mice. **P < 0.01.