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Tumor Volume Data and Example Fits. Shown are measured volumes (dots), tumor–volume fitted curves (solid) and fractional cell survival (S, dashed) for least-squares (LS) and slope-matched (SM) fitting. Data and curves are normalized to the tumor volume at time zero for the LS fit. Plots are shown for an (A) increase in E (Patient 5, Tumor 4); (B) no change in E (Patient 39, Tumor 3); (C) decrease in E (Patient 36, Tumor 3) for the LS fit relative to the SM fit, respectively.
