Table 2.
Parameter Ranges for Slope-Matched Fitting
| Parameter | Condition | Value (frequency) | |
|---|---|---|---|
| Tumor volume normalization |
|
Typical |
First 3 points (115) |
| |
|
Large cold effect |
First point (9) |
| |
|
Large decrease from points 1 to 2 and 3 |
Points 2 and 3 (8) |
| Radiosensitivity |
α, Gy−1 |
Match slope (therapy) |
Fitted |
| Cold sensitivity |
λp, gT/gp/h |
Match slope (tracer) |
Fitted |
| Clearance half-life |
Tc, d |
Typical |
3 (120) |
| |
|
Alternative values |
1 (1) |
| |
|
|
1.5 (2) |
| |
|
|
2 (9) |
| Clearance delay |
Td, d |
No delay |
0 (17) |
| |
|
Typical |
1.5 (112) |
| |
|
Long delay |
4 (3) |
| Effective cell doubling time | Tp, d (constant) | Mean time to progression | 150 |
Discrete values were chosen to provide adequate fits to tumor volume data, while only the radiosensitivity and cold-effect sensitivity parameters were continuously varied.