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. 2013 Dec 1;2(6):412–420. doi: 10.1089/biores.2013.0043

Table 1.

Scoring Matrix

Parameter Time point Smart Matrix vs. CCG Smart Matrix vs. Integra Smart Matrix vs. Matriderm
Matrix contraction
2
1
0
0
 
7
1
0
0
Cell viability+proliferation (alamarBlue assay)
2
0
0
1
 
7
0
0
0
Cell viability+proliferation (Ki67 expression)
2
0
0
0
 
7
0
0
0
Apoptosis (annexin V staining)
2
1
0
1
 
7
1
0
0
Morphology (SEM)
2
1
0
0
 
7
1
0
0
Morphology (H&E)
2
1
1
1
 
7
1
1
1
α-SMA expression
2
1
0
1
 
7
0
0
0
Cytokine and growth factor expression profile
 VEGF
2
0
0
0
 
7
0
0
0
 bFGF
2
0
0
0
 
7
0
0
0
 TGFβ
2
0
0
0
 
7
0
0
0
 TNFα
2
0
1
0
 
7
0
0
0
 IL-6
2
0
0
0
 
7
0
0
0
 IGF1
2
0
0
0
 
7
0
0
0
 Leptin
2
0
0
0
 
7
0
0
0
 EGF
2
0
0
0
 
7
0
0
0
Total 9 3 5

CCG, contractile collagen gel; SEM, scanning electron microscopy; H&E, hematoxylin and eosin; α-SMA, alpha-smooth muscle actin; VEGF, vascular endothelial growth factor; bFGF, fibroblast growth factor b; TGFβ, transforming growth factor beta; TNFα, tumor necrosis factor alpha; IL, interleukin; IGF1, insulin-like growth factor 1; EGF, epidermal growth factor.