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. 2013 Dec 1;2(6):431–439. doi: 10.1089/biores.2013.0040

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 6. — Effect of MTX and AZA on the capacity of NK and CD8 T cells to lyse allogeneic ASCs. (A) Pre-activated and sorted CD8 T and NK cells lyse ASCs in a ratio-dependent manner (●). The presence of MTX (100 μg/mL; ) did not affect the lysis of the ASCs while AZA (1 μM; ○) reduced the lysis mediated by NK cells even at low ratios of 2.5:1. Mean and standard deviations of four experiments are shown. *p<0.05, **p<0.01, ***p<0.001. (B) Apoptosis was tested on NK cells with ASCs at different ratios (40:1 to 10:1) or without ASCs (40:0). Black bars represent no drug, white bars represent AZA (1 μM) and gray bars represent MTX (100 μg/mL). (C) Representative plots of the apoptosis on NK cells in the presence of ASCs at a 40:1 ratio with or without AZA or MTX.

Inline graphic — Effect of MTX and AZA on the capacity of NK and CD8 T cells to lyse allogeneic ASCs. (A) Pre-activated and sorted CD8 T and NK cells lyse ASCs in a ratio-dependent manner (●). The presence of MTX (100 μg/mL; ) did not affect the lysis of the ASCs while AZA (1 μM; ○) reduced the lysis mediated by NK cells even at low ratios of 2.5:1. Mean and standard deviations of four experiments are shown. *p<0.05, **p<0.01, ***p<0.001. (B) Apoptosis was tested on NK cells with ASCs at different ratios (40:1 to 10:1) or without ASCs (40:0). Black bars represent no drug, white bars represent AZA (1 μM) and gray bars represent MTX (100 μg/mL). (C) Representative plots of the apoptosis on NK cells in the presence of ASCs at a 40:1 ratio with or without AZA or MTX.