FIG. 2.

Representative pressure-volume loops at baseline and after infusion of Oxyglobin. (A) Experimental timeline. Rats were stabilized for 30 min after surgery before cardiac performance was measured. Blood gasses were drawn as indicated (BG1 and BG2). Purified human hemoglobin (8.1 mM) was infused until a target dose of 175 mg/kg was attained. Rats were monitored for 1 h after hemoglobin infusion. Pressure-volume loops were measured in (B) right ventricles and (C) left ventricles in situ. Steady-state loops from a control (black) and with hemoglobin infusion (gray) are shown. The lines represent the ESPVR. RV, right ventricles; LV, left ventricles.