FIG. 4.

Comparison of other metabolic parameters between WT and Tg mice following induction of the nongenetic mouse model. (A) BW was not significantly different between WT and Tg mice at weeks 0 and 4 of HFrD feeding and STZ injection (HFrD+STZ, n=10 mice per group). Therefore, this nongenetic mouse model did not exhibit overt obesity. (B) BW and organ/BW ratios were not significantly different between Tg and WT mice at 4 weeks after STZ injection (HFrD+STZ, n=10 mice per group). (C) Although food consumption was slightly, but not significantly increased after STZ injection than before STZ injection in Tg and WT mice (HFrD+STZ, n=10 mice per group), it was similar in Tg and WT mice at both times. (D) Serum cholesterol level. Upper, a representative serum cholesterol profile is shown, determined by HPLC in a mouse fed the HFrD for 8 weeks and injected with STZ injection (HFrD+STZ, n=10 mice per group). The concentration of lipoproteins is shown on the y axis (mV), and elution time is indicated on the x axis. Bottom, WT and Tg mice developed modest hypolipidemia with mild reductions of T-cho, VLDL, LDL, and TG. However, serum T-cho, LDL, and HDL levels were significantly higher and TG levels were significantly lower in Tg mice than in WT mice. There were no significant differences in VLDL or FFA levels between the two groups. *p<0.05. Values are means±SE. FFA, free fatty acid; LDL, low-density lipoprotein; VLDL, very low-density lipoprotein; TG, triglyceride; T-cho, total cholesterol; HDL, high-density lipoprotein.