Table 2.
Physical properties of ISMN (Isosorbide-5-mononitrate) matrix tablets
| Formulation | Weight variation (n = 20) | Drug content* (%) | Hardness (Kg/cm 2 ) (n = 10) | Friability | Thickness (mm) (n = 10) |
|---|---|---|---|---|---|
| F1 | 209.5 ± 3.1 | 99.6 ± 0.45 | 6.90 ± 0.12 | 0.31 | 4.20 ± 0.04 |
| F2 | 208.7 ± 3.1 | 99.2 ± 0.21 | 5.60 ± 0.21 | 0.12 | 4.23 ± 0.01 |
| F3 | 209.2 ± 3.0 | 98.5 ± 0.045 | 5.40 ± 0.02 | 0.39 | 4.24 ± 0.02 |
| F4 | 210.1 ± 5.3 | 100.4 ± 0.63 | 4.60 ± 0.26 | 0.34 | 4.21 ± 0.01 |
| F5 | 209.0 ± 3.5 | 99.3 ± 0.20 | 7.25 ± 0.98 | 0.40 | 4.20 ± 0.00 |
| F6 | 209.0 ± 3.9 | 100.3 ± 0.12 | 6.77 ± 0.96 | 0.50 | 4.22 ± 0.02 |
*Mean of triplicate with SD