Table 1. Cardiac function of WT and TG mice.

	2 months		10 months
	WT (n=5-10)	TG (n=5-12)	WT (n=8)	TG (n=10)
HR, bpm	662 ± 21	435 ± 45 *	707 ± 32	451 ± 23 †
AWd, mm	0.89 ± 0.07	0.77 ± 0.11 *	0.99 ± 0.11	0.89 ± 0.10 †
PWd, mm	0.86 ± 0.06	0.78 ± 0.06 *	1.03 ± 0.16	0.94 ± 0.08 †
LVDs, mm	1.47 ± 0.20	3.07 ± 0.32 *	1.54 ± 0.24	3.27 ± 0.43 †
LVDd, mm	3.10 ± 0.18	4.19 ± 0.19 *	3.28 ± 0.27	4.38 ± 0.41 †
&emspEF, %	83.9 ± 4.7	52.5 ± 7.8 *	85.1 ± 7.8	50.2 ± 8.3 †
&emspBW, g	26.0 ± 1.7	26.0 ± 1.6	35.5 ± 3.3	36.1 ± 2.1
LVP, mmHg	90.1 ± 2.5	93.2 ± 4.6
LV dp/dt max, mmHg/sec	5963 ± 467	4265 ± 94 *
LV dp/dt min, mmHg/sec	-5240 ± 251	-3866 ± 152 *

HR: heart rate; AWd: anterior wall diameter; PWd: posterior wall diameter; LVDd: left ventricular diastolic diameter; LVDs: left ventricular systolic diameter; EF: ejection fraction; LVP: left ventricular systolic pressure; LV dp/dtmax, the maximum rate of left ventricular pressure rise; LV dp/dt min, the maximum rate of left ventricular pressure decrease; Values are expressed as mean ± SD. n indicates number of mice;

^*P<0.05 vs WT at 2 months,

^†P<0.05 vs WT at 10 months.