Table 1.
Subject demographics.
| HEALTHY | CF | |||
|---|---|---|---|---|
| ALL | HETEROZYGOUS ΔF508 | HOMOZYGOUS ΔF508 | ||
| N | 16 | 16 | 3 | 13 |
| Homozygous ΔF508 n (%) | 0 | 13(81) | – | – |
| Gender (% female) | 50 | 25 | 0 | 69 |
| Age (years) | 25 ± 6 | 22 ± 8 | 25 ± 12 | 22 ± 7 |
| Height (cm) | 169 ± 8 | 166 ± 8 | 166 ± 11 | 166 ± 8 |
| Weight (kg) | 64 ± 9 | 60 ± 9 | 66 ± 12 | 58 ± 8 |
| BMI (kg/m2) | 23 ± 3 | 22 ± 3 | 24 ± 1 | 21 ± 3 |
| BSA (m2) | 1.7 ± 0.1 | 1.7 ± 0.2 | 1.7 ± 0.2 | 1.6 ± 0.1 |
| Hemoglobin (g/dL) | 14.3 ± 1.3 | 14.6 ± 1.5 | 15.8 ± 0.6 | 14.2 ± 1.5 |
| VO2PEAK (% predicted) | 108 ± 35 | 54 ± 24* | 54 ± 11 | 53 ± 26 |
Note: Values are mean ± SD *P < 0.01 vs. healthy. Statistics not performed on ΔF508 groups.
Abbreviations: CF, cystic fibrosis; BMI, body mass index; BSA, body surface area; VO2peak, maximal oxygen consumption.