Table 2.
Baseline pulmonary function parameters.
| HEALTHY | CF | |||
|---|---|---|---|---|
| ALL | HETEROZYGOUS ΔF508 | HOMOZYGOUS ΔF508 | ||
| FVC (L) | 4.6 ± 1.3 | 3.5 ± 0.9* | 3.8 ± 1.1 | 3.4 ± 0.9 |
| FVC (% predicted) | 101 ± 19 | 82 ± 20* | 85 ± 13 | 82 ± 21 |
| (FEV)1 (L) | 3.7 ± 0.8 | 2.5 ± 0.8* | 2.7 ± 0.9 | 2.4 ± 0.9 |
| (FEV)1 (% predicted) | 97 ± 16 | 70 ± 25* | 74 ± 21 | 69 ± 26 |
| (FEV)1 (/FVC (%) | 83 ± 1 | 70 ± 1* | 71 ± 9 | 70 ± 1 |
| (FEF)25–75 (mL) | 3.8 ± 1.0 | 1.9 ± 1.1* | 2.0 ± 1.0 | 1.9 ± 1.2 |
| (FEF)25–75 (% predicted) | 93 ± 24 | 51 ± 31* | 51 ± 29 | 51 ± 33 |
Note: Values are mean ± SD *P < 0.01 vs. healthy. Statistics not performed on ΔF508 groups.
Abbreviations: CF, cystic fibrosis; FVC, forced vital capacity; FEV1, forced expiratory volume after one second of FVC; FEF25–75, forced expiratory flow at 25–75% of FVC.