Table 1.
Prevalence of potential drug-drug interactions (n=151)-IPD
| Interacting drugs | Potential adverse outcome | Number of prescriptions |
|---|---|---|
| Anticoagulant therapy + Clopidogrel + Aspirin | Increased risk of bleeding | 59 |
| Clopidogrel+PPIs | Increased risk of thrombosis | 51 |
| Ramipril + Spironolactone | Hyperkalemia | 10 |
| Furosemide + Ramipril | Postural hypotension | 5 |
| Spironolactone + Digoxin | Digoxin toxicity | 4 |
| Alprazolam + Digoxin | Digoxin toxicity (nausea, vomiting, arrhythmia) | 4 |
| Diltiazem + Atorvastatin | Increased risk of rhabdomyolysis | 2 |
| Heparin + Aspirin | Increased risk of bleeding | 2 |
| Theophylline + Ciprofloxacin | Increased Theophylline toxicity | 2 |
| Metronidazole + Warfarin | Increased risk of bleeding | 2 |
| Warfarin + Pantoprazole | Increased INR and prothrombin time | 2 |
| Insulin + Ciprofloxacin | Increased risk of hypoglycemia or hyperglycemia | 2 |
| Diltiazem + Carvedilol | Increased risk of hypotension, bradycardia, AV conduction disturbance | 2 |
| Hydrochlorthiazide + Ramipril | Postural hypotension | 1 |
| Rifampicin + Isoniazid | Hepatotoxicity | 1 |
| Diltiazem+metoprolol | Increased risk of hypotension, bradycardia, AV conduction disturbance | 1 |
| Amoxicillin+warfarin | Increased risk of bleeding | 1 |