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. 2013 Jun 11;3(4):431–457. doi: 10.1002/brb3.142

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© 2013 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Ventral roots atrophy, but absolute number of axons are not reduced by P75. Ventral root axons from L3, L4, and L5 segments of spinal cord were counted to determine if there was a degeneration of ventral roots associated with the apparent degeneration of MNs and interneurons at day 75. There was no significant difference in the area of (B) or number of (C) axons in SOD1 versus WT ventral roots (t-test with Bonferroni correction). Many axons in the SOD1 mouse, however, exhibited alterations indicative of ongoing or impending demyelination/degeneration (see enlarged boxed regions in A). n = 6 animals/genotype.