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. 2013 Dec 20;8(12):e82239. doi: 10.1371/journal.pone.0082239

Figure 1. Schematic diagram illustrating direct and indirect pathways connecting mossy fibers (MF) to GLIs.

Figure 1

Arrows indicate the directionality of the signal flow. Granule cells (GrC) receive glutamategic inputs from MFs and UBCs, and glycinergic/GABAergic inputs from Golgi cells (GoC). Unipolar Brush cells (UBC) receive a single mossy fiber input and glycinergic/GABAergic inputs from nearby Golgi cells. UBCs in turn establish glutamatergic synapses with granule cells and other UBCs. Golgi cells receive glutamatergic inputs from mossy fibers and parallel fibers, and glycinergic/GABAergic inputs from other Golgi cells. For simplicity we show only the classical major connections and interneurons of the granular layer. We also separate them between glutamatergic pathways (green) and glycinergic/GABAergic pathways (blue), although we acknowledge that other neurotransmitters, pathways, and interneurons exist. Axons and dendrites are represented by thick and thin traces respectively.