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. 2013 Dec 20;8(12):e83029. doi: 10.1371/journal.pone.0083029

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© 2013 Hrabovszky et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Bar graph illustrates the low percentages of tyrosine hydroxylase-immunoreactive dopaminergic neuronal cell bodies that receive innervation from orexin B-immunoreactive axons in the ventral tegmental area (VTA) and substantia nigra (SN) of adult male humans and rats. Note that while the axo-somatic innervation is quite sparse in both species, the percentage of dopaminergic cell bodies receiving orexinergic input is 5-times higher in the human compared with the rat VTA and 2.2-times higher in the human compared with the rat SN. *p<0.05; **p<0.01.