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. 2013 Dec 20;8(12):e83029. doi: 10.1371/journal.pone.0083029

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© 2013 Hrabovszky et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The mean percentages of orexin B-immunoreactive contacts that target the dendritic compartment of dopaminergic neurons were calculated from the first randomly encountered one hundred orexin B/TH appositions in each human individual and in each rat. Both in the ventral tegmental area (VTA) and the substantia nigra (SN) and both in humans and rats, the vast majority (86–88%) of orexinergic inputs to dopaminergic neurons is axo-dendritic.