Table 2. Generated probe sets for melphalan resistance weighted and re-weighted.
Probe ID | Gene Symbol | Location | Weight | New Weights |
204204_at | SLC31A2 | 9q31-q32 | −0.025 | −0.507 |
219748_at | TREML2 | 6p21.1 | −0.033 | −0.38 |
203708_at | PDE4B | 1p31 | −0.053 | −0.319 |
201990_s_at | CREBL2 | 12p13 | −0.046 | −0.314 |
219049_at | CSGALNACT1 | 8p21.3 | −0.037 | −0.226 |
218751_s_at | FBXW7 | 4q31.3 | −0.044 | −0.184 |
212055_at | C18orf10 | 18q12.2 | 0.025 | −0.184 |
205990_s_at | WNT5A | 3p21-p14 | −0.065 | −0.077 |
204786_s_at | IFNAR2 | 21q22.1, 21q22.11 | −0.033 | −0.0522 |
217825_s_at | UBE2J1 | 6q15 | −0.02 | 0.0401 |
201889_at | FAM3C | 7q31 | −0.039 | 0.074 |
206405_x_at | USP6 | 17p13 | −0.038 | 0.0888 |
203895_at | PLCB4 | 20p12 | −0.015 | 0.0982 |
212122_at | RHOQ | 2p21 | −0.016 | 0.137 |
205862_at | GREB1 | 2p25.1 | −0.034 | 0.187 |
221210_s_at | NPL | 1q25 | 0.032 | 0.189 |
213555_at | RWDD2A | 6q14.2 | −0.019 | 0.195 |
217104_at | ST20 | 15q25.1 | 0.012 | 0.201 |
202043_s_at | SMS | Xp22.1 | 0.011 | 0.486 |
The first four columns contain a list of probes, genes, location and weights for candidate biomarkers obtained by comparing gene expression data between melphalan sensitive and resistant B cell lines (11). In the fifth column the candidate gene list has undergone an in vivo disease reweighting by PFS in the MRC Myeloma IX training set.