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. 2013 Dec 20;8(12):e84187. doi: 10.1371/journal.pone.0084187

Figure 7. CD109 positively regulates ALDH activity and negatively regulates the TGFβ/Smad signaling pathway.

Figure 7

A. The cell proliferation curve of ESX treated with SiCD109 or control siRNA. Bars represent mean±SEM (n=4). ※ p<0.05, determined by the Mann-Whitney test.

B, C. mRNA expression of ALDH1A1 (D) and TGFβ1R1 (E). The expression of ALDH1A1 and TGFβ1R1 was evaluated by real-time PCR two days after transfection.

D. FACS analysis of ALDH activity.

E. The proportion of ALDHhigh cells. Bars represent mean±SEM (n=4). ※ p<0.05, determined by the Mann-Whitney test.