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AR79 increases cell growth of DU145 and C4-2B cell lines via activating canonical Wnt signaling. DU145 and C4-2B parental cells (control) and cells transfected with scrambled or β-catenin siRNAs were grown in 96-well plates. Cells were then treated with AR79 (3μg/ml) and rhWnt3a (60ng/ml) or vehicle (DMSO or PBS) for 24hr, 48hr and 72hr. Cell numbers were measured using WST-1. Data are presented as mean±SD from triplicate determinations.
