Fig. 2.

High-resolution, cross-sectional images of mouse tongue epithelium corresponding to areas imaged with widefield autofluorescence imaging. Confocal autofluorescence images [(a) to (e)] are matched with H&E-stained histology sections [(f) to (j)] from the same specimen. Images are grouped by pathology grade: normal [(a) and (f)], mild dysplasia [(b) and (g)], moderate dysplasia [(c) and (h)], severe dysplasia [(d) and (i)], and squamous cell carcinoma [(e) and (j)]. Arrows indicate hyperkeratosis. Qualitative features of the confocal autofluorescence images for the keratin, epithelial cell, and stromal collagen layers are listed in the table below the figure. Scale bars are 100 μm.