Table 2. VRP, CsA, and RES enhanced UA-mediated cytotoxicity in Ca3/7 cells, indicated by a decrease in the IC50 for UA (average of 3-4 independent experiments, n=3/exp).
| compound | dose | fold decrease of IC50 | p-value |
|---|---|---|---|
| +veh | 1 | ||
| +5 μM | 1.22±0.1 | p<0.01 | |
| VRP | +10 μM | 1.22±0.13 | p<0.05 |
| +25 μM | 1.86±0.32 | p<0.05 | |
| +50 μM | 1.85±0.15 | p<0.0001 | |
| +100 μM | 2.85±0.41 | p<0.005 | |
| +veh | 1 | ||
| +5 μM | 1.34±0.06 | p<0.005 | |
| CsA | +10 μM | 1.53±0.2 | p<0.05 |
| +25 μM | 1.82±0.27 | p<0.05 | |
| +50 μM | 1.96±0.43 | p<0.05 | |
| +100 μM | 1.93±0.39 | p<0.05 | |
| +veh | 1 | ||
| +5 μM | 0.91±0.16 | ||
| RES | +10 μM | 1.0±0.29 | |
| +25 μM | 1.35±0.15 | p<0.01 | |
| +50 μM | 1.42±0.17 | p<0.005 | |
| +100 μM | 2.31±0.52 | p<0.01 |