Table 11.
Characteristic | Estimated difference in proportion reporting | p-value | ||||||
---|---|---|---|---|---|---|---|---|
Patient Control | Shared Control | Physician Control | ||||||
Observed | Synthetic | Observed | Synthetic | Observed | Synthetic | Observed | Synthetic | |
Level of evidence for treatment | < 0.001 | < 0.001 | ||||||
Evidence for | * | * | * | * | * | * | ||
Uncertain | 5.7 (1.4) | 5.7 (1.4) | −4.2 (1.4) | −4.0 (1.4) | −1.6 (1.0) | −1.6 (1.0) | ||
No evidence for | −1.8 (1.8) | −1.7 (1.8) | −2.6 (1.7) | −2.6 (1.7) | 4.4 (1.2) | 4.3 (1.2) | ||
Missing | 5.2 (2.7) | 5.0 (2.7) | −3.8 (2.6) | −3.6 (2.6) | −1.4 (1.8) | −1.5 (1.8) | ||
Preference sensitive |
< 0.001 | < 0.001 | ||||||
No | * | * | * | * | * | * | ||
Yes | −6.5 (1.5) | −6.2 (1.5) | 1.5 (1.6) | 1.4 (1.6) | 4.8 (1.2) | 4.8 (1.2) | ||
Treatment modal- ity |
< 0.001 | < 0.001 | ||||||
Surgery | * | * | * | * | * | * | ||
Radiation | −2.7 (1.2) | −2.6 (1.2) | 2.2 (1.2) | 2.2 (1.2) | 0.5 (0.9) | 0.4 (0.9) | ||
Chemotherapy | 4.3 (0.9) | 4.3 (0.9) | −1.4 (0.9) | −1.3 (0.9) | −2.9 (0.7) | −3.0 (0.7) | ||
Received treatment | < 0.001 | < 0.001 | ||||||
No | * | * | * | * | * | * | ||
Yes | 3.9 (1.4) | 3.9 (1.4) | 12.3 (1.3) | 12.4 (1.4) | −16.2 (1.2) | −16.3 (1.3) | ||
Cancer site | 0.54 | 0.59 | ||||||
Lung | * | * | * | * | * | * | ||
Colorectal | −0.7 (1.5) | −0.4 (1.6) | −0.5 (1.5) | −0.6 (1.5) | 1.2 (1.0) | 1.0 (1.1) | ||
Age at diagnosis (yrs) | 0.19 | 0.92 | ||||||
21-55 | * | * | * | * | * | * | ||
56-70 | 1.6 (2.1) | 2.6 (3.5) | 1.2 (2.1) | −2.7 (2.4) | −2.8 (1.4) | 0.1 (2.0) | ||
71-80 | 1.4 (2.3) | 1.9 (2.0) | 0.9 (2.2) | −1.7 (2.4) | −2.2 (1.5) | −0.1 (1.6) | ||
≥ 81 | 1.4 (2.3) | 0.6 (4.1) | −1.4 (2.3) | −2.5 (2.5) | 0.1 (1.6) | 1.8 (2.8) | ||
Sex | 0.28 | 0.85 | ||||||
Male * | * | * | * | * | * | |||
Female | −2.0 (1.3) | 0.3 (1.9) | 1.1 (1.3) | −0.8 (1.8) | 1.0 (1.0) | 0.5 (1.0) | ||
Ethnicity | 0.05 | 0.64 | ||||||
White | * | * | * | * | * | * | ||
Black | 1.4 (1.9) | −1.4 (2.8) | 1.6 (1.9) | 0.7 (2.5) | −3.0 (1.3) | 0.7 (2.5) | ||
Hispanic | −5.1 (2.5) | −4.4 (3.7) | 4.4 (2.6) | 0.8 (3.3) | 0.7 (1.9) | 3.7 (2.4) | ||
Asian | −2.2 (3.0) | 0.6 (3.7) | −2.3 (3.0) | −2.8 (3.4) | 4.4 (2.5) | 2.1 (2.7) | ||
Other | 0.7 (2.8) | 1.2 (3.3) | 1.7 (2.9) | −0.8 (3.1) | −2.4 (1.9) | −0.4 (2.8) | ||
Marital status | 0.005 | 0.42 | ||||||
Married | * | * | * | * | * | * | ||
Not married | −0.2 (1.4) | 1.3 (1.4) | −3.0 (1.4) | −2.1 (1.6) | 3.2 (1.1) | 0.7 (1.1) | ||
Education | 0.07 | 0.58 | ||||||
< High school (HS) | −2.1 (1.8) | −0.5 (1.8) | 0.6 (1.8) | 0.1 (2.2) | 1.5 (1.3) | 0.6 (1.6) | ||
HS graduate or some college |
* | * | * | * | * | * | ||
College degree or higher |
3.3 (1.5) | 3.2 (2.0) | −1.8 (1.5) | −2.9 (1.8) | −1.5 (1.0) | −0.3 (1.6) | ||
Income $ | 0.08 | 0.08 | ||||||
< 20,000 | 2.3 (2.1) | 1.2 (2.1) | −1.3 (2.1) | −2.3 (2.1) | 1.0 (1.5) | 1.0 (1.5) | ||
20,000 to < 40,000 | −2.5 (1.8) | −3.1 (1.8) | 2.4 (1.9) | 1.7 (1.9) | 0.1 (1.3) | 1.5 (1.4) | ||
40,000 to < 60,000 | −0.9 (1.9) | −1.2 (1.9) | −0.7 (1.9) | −1.2 (1.9) | 1.7 (1.5) | 2.4 (1.5) | ||
≥ 60,000 | * | * | * | * | * | * | ||
No. self-reported comorbid conditions | 0.79 | 0.77 | ||||||
0 | * | * | * | * | * | * | ||
1 | 1.8 (1.4) | 1.8 (1.4) | −1.8 (1.4) | −1.9 (1.4) | −0.1 (1.0) | 0.0 (1.0) | ||
2 | 1.3 (1.9) | 1.2 (1.9) | −2.3 (1.9) | −2.4 (1.9) | 1.0 (1.4) | 1.1 (1.4) | ||
≥ 3 | 0.8 (2.6) | 0.9 (2.6) | −0.2 (2.7) | −0.3 (2.6) | −0.6 (1.9) | −0.6 (1.9) | ||
Prediagnosis health status | 0.02 | 0.02 | ||||||
Quartile 1 | * | * | * | * | * | * | ||
Quartile 2 | 0.4 (1.7) | 0.4 (1.7) | 1.0 (1.7) | 0.8 (1.7) | −1.3 (1.2) | −1.1 (1.2) | ||
Quartile 3 | 4.9 (1.8) | 4.9 (1.8) | −2.8 (1.8) | −3.0 (1.8) | −2.1 (1.3) | −1.9 (1.3) | ||
Quartile 4 | 3.7 (1.8) | 3.8 (1.8) | −0.4 (1.8) | −0.5 (1.8) | −3.3 (1.2) | −3.3 (1.2) | ||
CES-D short form | 0.26 | 0.28 | ||||||
≤ 5 | * | * | * | * | * | * | ||
≥ 6 | 2.6 (1.7) | 2.2 (1.7) | −2.7 (1.7) | −2.4 (1.7) | 0.1 (1.3) | 0.2 (1.3) | ||
Study site | < 0.001 | < 0.001 | ||||||
Los Angeles county | * | * | * | * | * | * | ||
Alabama | −1.7 (2.3) | −0.9 (2.3) | 5.7 (2.3) | 5.6 (2.3) | −4.1 (1.5) | −4.7 (1.5) | ||
8 counties in North California |
2.5 (1.9) | 2.0 (1.9) | −2.2 (1.9) | −2.2 (1.9) | −0.3 (1.3) | 0.1 (1.3) | ||
22 counties in east- ern North Carolina |
−8.4 (2.1) | −7.9 (2.2) | 11.2 (2.4) | 10.9 (2.4) | −2.8 (1.5) | −3.0 (1.5) | ||
Iowa | 1.1 (2.6) | 1.3 (2.6) | 4.0 (2.7) | 3.4 (2.7) | −5.1 (1.5) | −4.7 (1.5) | ||
5 HMOs | −1.1 (2.1) | −0.9 (2.1) | 2.1 (2.1) | 1.8 (2.1) | −1.1 (1.4) | −0.9 (1.4) | ||
15 Veterans Affairs hospitals |
0.2 (2.4) | 1.8 (2.5) | 1.9 (2.5) | 1.1 (2.5) | −2.1 (1.7) | −2.9 (1.7) |
reference group