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. Author manuscript; available in PMC: 2013 Dec 21.
Published in final edited form as: Curr Opin Immunol. 2010 Mar 17;22(2):10.1016/j.coi.2010.02.011. doi: 10.1016/j.coi.2010.02.011

Figure 2. Ikaros effects on priming of lymphoid lineage potential.

Figure 2

A. Ikaros effects on the lymphoid and myeloid differentiation pathways. Ikaros is required for the generation of the CLP and ETP by priming lymphoid lineage-specific signatures in the HSC and LMPP. B. Ikaros activates an extensive lymphoid transcriptional program while it represses smaller cohorts of myeloid-, stem cell-and erythroid-specific genes in the HSC and LMPP. Key downstream targets of Ikaros that are positively (green arrow) or negatively (red block) regulated are shown in the diagram. Signature affiliation, gene function and sub-cellular localization of these genes also are indicated.