Table 5.
Genetic data identifying roles for ion channels or gap junctions in cancer. Several ion transporters are now recognized as causal agents in carcinogenesis, consistent with the role of Vmem in regulating cell proliferation, migration and differentiation
| Protein | Species | Reference |
|---|---|---|
| NaV1.5 sodium channel | Human | House et al. 2010; Onkal and Djamgoz 2009 |
| EAG-1 potassium channel | Human | Pardo et al. 1999 |
| KCNK9 potassium channel | Mouse | Pei et al. 2003 |
| Ductin (proton V-ATPase component) |
Mouse | Saito et al. 1998 |
| SLC5A8 sodium/butyrate transporter |
Human | Gupta et al. 2006 |
| KCNE2 potassium channel | Mouse | Roepke et al. 2010 |