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. 2012 May 21;34(48):3717–3727. doi: 10.1093/eurheartj/ehs106

Figure 3.

Figure 3

Disruption of transforming growth factor beta signalling in CD11c+ cells increases T cell proliferation and cytokine expression. (A) T cell proliferation (×104 cpm, n = 3, *P < 0.05). Bone marrow-derived CD11c+ cells from CD11cDNR mice co-cultured with wild-type CD4+ T cells (magnetic bead-isolated). (B–E) Cytokine expression, concentrations (pg/mL) of (B) interferon-γ, (C) IL-4, (D) IL-10, and (E) IL-17 in supernatants of cultured splenocytes from Apoe−/− and Apoe−/−CD11cDNR mice (n = 5, *P < 0.05), stimulated with anti-CD3/CD28 antibodies. Disruption of transforming growth factor beta signalling in bone marrow-derived CD11c+ cells co-cultured with wild type T cells increases (F) interferon-γ and (G) IL-4 cytokine expression (n = 8, *P < 0.05).