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. Author manuscript; available in PMC: 2013 Dec 21.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):10.1167/iovs.12-10528. doi: 10.1167/iovs.12-10528

Figure 5. Immunostimulation of TLR3 by siRNAs.

Figure 5

A synthetic analog of dsRNA (poly I:C-LMW), was used as a positive control for immunostimulation of TLR3 in the corneal epithelial cells. RT-PCR showed increased levels of TLR3 in the presence of this agonist while cells treated with K12-Arg135Thr-5 siRNA at 0.5 and 5nM for 24h or 48h show no obvious increase at the times and concentrations assessed. An earlier time point of 6h was also assessed and no obvious increase in TLR3 was noted (data not shown).