Table 3.
Projects approved for study within the registry, 2000–10
| Year approved | Project title | References |
|---|---|---|
| 2002 | Immunological characterization of the infiltrate in JDM muscle | [24, 26, 27] |
| 2002 | Tracking of lymphocyte changes before or after flare of active disease | |
| 2002 | Analysis of MHC Class 1 expression in an animal model of myositis | [29, 30] |
| 2002 | Recognition of MHC Class 1 molecules on muscle cells by lymphocytes (CD8 T cells or NK cells) | [18, 24–27] |
| 2002 | The role of muscle ultrasound and MRI in juvenile dermatomyositis | [31, 32] |
| 2004 | Investigation of alterations of MRP8/14 proteins in juvenile dermatomyositis | Ongoing study |
| 2004 | Autoantibodies and HLA haplotypes in juvenile dermatomyositis, juvenile scleroderma and overlap syndromes | [6, 33, 34] |
| 2004 | Do functional gene variants in anti-inflammatory pathways alter the course of disease and allow greater inflammatory response? | [35, 36] |
| 2005 | Design and testing/validation of a score tool for assessing severity in JDM | [18] |
| 2005 | Fetuin-A and calcinosis in juvenile dermatomyositis | [28] |
| 2005 | Genotyping analysis in JDM for phenotype–genotype correlation | [6, 35, 36] |
| 2006 | Is there evidence of maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis? | Ongoing study |
| 2006 | Extension for genotyping analysis in JDM for phenotype: genotype correlation | [36] |
| 2008 | Genome-wide association study of the idiopathic inflammatory myopathies (collaboration with MYOGEN consortium) | Ongoing study |
| 2008 | Vasculopathy of JDM | Ongoing study |
| 2009 | Fatigue in children with juvenile dermatomyositis | Ongoing study |
| 2009 | A survey of current practice in treatment of juvenile dermatomyositis in the UK and Ireland | Ongoing study |
| 2009 | Development of classification criteria for the idiopathic inflammatory myopathies and their major subgroups (collaboration with IMACS) | Ongoing study |
| 2009 | Five year single blind, phase III effectiveness randomized actively controlled clinical trial in new onset juvenile dermatomyositis: prednisolone versus prednisolone plus cyclosporin A versus prednisolone plus methotrexate (collaboration through PRINTO) | Ongoing study |
| 2010 | IMACS Outcomes Repository (collaboration with IMACS) | Ongoing study |