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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Trends Cardiovasc Med. 2013 Jul 26;24(2):75–80. doi: 10.1016/j.tcm.2013.06.007

Figure 1. The feedback loop to regulate glucose transport by TXNIP.

Figure 1

TXNIP expression is increased by glucose via glucose-dependent transcriptional regulations by carbohydrate response element binding protein (ChREBP) and MondoA:Mlx. The induction of TXNIP under hyperglycemia inhibits further glucose uptake by feedback regulation.