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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Trends Cardiovasc Med. 2013 Jul 26;24(2):75–80. doi: 10.1016/j.tcm.2013.06.007

Figure 2. TXNIP interacts with von Hippel-Lindau protein (pVHL) to promote ubiquitin (Ub)-induced degradation of HIF-1α.

Figure 2

HIF-1α protein is rapidly degraded by pVHL with TXNIP under normoxia. Under hypoxic conditions, HIF-1α degradation is inhibited to activate glycolytic target genes that regulate mitochondrial oxidative phosphorylation. Blocking of TXNIP relieves the destabilization of HIF1α. HIF-1α expression is also up-regulated by thioredoxin.