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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Trends Cardiovasc Med. 2013 Jul 26;24(2):75–80. doi: 10.1016/j.tcm.2013.06.007

Figure 4. Mitochondrial metabolism in TXNIP-deletion cardiomyocytes.

Figure 4

TXNIP deficiency reprograms glucose metabolism in cardiomyocytes to a high flux glycolytic state in association with reduced activity of pyruvate dehydrogenase (PDH) and increased cytosolic lactate production maintaining energy homeostasis.