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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Heart Rhythm. 2013 Oct 4;10(12):10.1016/j.hrthm.2013.09.064. doi: 10.1016/j.hrthm.2013.09.064

Figure 4.

Figure 4

Both WT and Q7R-FGF12 rescue Ca2+ current density and localization from FGF13 KD. A: Representative Ca2+ current traces from the 4 groups. B: I–V curve depicting the rescue of CaV1.2 current density with WT and Q7R-FGF12. Peak current densities at 0 mV are −13.01 ± 0.88 pA/pF (n = 9) for control, −8.09 ± 1.30 pA/pF (n = 13) for FGF13 KD, −12.86 ± 1.50 pA/pF (n = 13) for FGF13 KD + WT-FGF12, and −17.05 ± 1.46 (n = 13) for FGF13 KD + Q7R-FGF12. C: Immunostaining for CaV1.2 (green) and ryanodine receptor (red) showing that CaV1.2 is mislocalized with FGF13 KD and the localization is rescued with WT and Q7R-FGF12. *P < .05 versus control. FGF = fibroblast growth factor; KD = knocked down; WT = wild type.