Table 4.
Regions show consistent gray matter reduction and relative preservation in the old group relative to the young group.
| Volume (mm3) | Label | MNI coordinates | Extrema Value | Contributed studies # | ||
|---|---|---|---|---|---|---|
|
| ||||||
| x | y | z | ||||
| Gray matter reduction | ||||||
| 2936 | L. Postcentral Gyrus, BA 2 | −56 | −26 | 46 | 0.0241 | 2, 3, 5, 9, 10, 11, |
| L. Postcentral Gyrus, BA 3 | −50 | −16 | 36 | 0.0232 | 14, 15, 16, 17 | |
| L. Precentral Gyrus, BA 4 | −48 | −14 | 44 | 0.0200 | ||
| 1720 | L. Inferior Frontal Gyrus, BA 9 | −48 | 12 | 32 | 0.0243 | 2, 4, 6, 12, 13, 15, |
| L. Precentral Gyrus, BA 6 | −46 | 2 | 32 | 0.0188 | 17 | |
| 1360 | L. Insula, BA 13 | −44 | −4 | −4 | 0.0275 | 5, 13, 15, 16, 17, |
| L. Insula, BA 13 | −44 | −16 | 0 | 0.0155 | 18a, 18b, 22 | |
| L. Insula, BA 13 | −40 | −22 | 8 | 0.0152 | ||
| 1304 | R. Insula | 44 | −10 | −2 | 0.0355 | 5, 13, 17, 18a, 18b, 22 |
| 1296 | L. Medial Frontal Gyrus, BA 6 | 0 | 40 | 32 | 0.0210 | 2, 5, 9, 16, 20, 21, 22 |
| 1232 | R. Insula, BA 13 | 42 | −16 | 12 | 0.0185 | 2, 6, 11, 15, 16, 17 |
| R. Insula, BA 13 | 44 | −12 | 20 | 0.0177 | ||
| 1224 | L. Caudate Body | −2 | 4 | 6 | 0.0188 | 1, 3, 6, 11, 17, 18a, |
| L. Thalamus | 0 | −2 | 6 | 0.0185 | 18b | |
| R. Thalamus | 8 | −6 | 14 | 0.0139 | ||
| 1136 | R. Inferior Frontal Gyrus, BA 9 | 58 | 24 | 20 | 0.0176 | 2, 5, 10, 17, 20, 21 |
| R. Inferior Frontal Gyrus, BA 9 | 50 | 12 | 28 | 0.0173 | ||
| R. Precentral Gyrus, BA 6 | 50 | 8 | 34 | 0.0150 | ||
| 944 | L. Inferior Frontal Gyrus, BA 47 | −46 | 16 | −10 | 0.0205 | 5, 10, 20, 21, 22 |
| L. Inferior Frontal Gyrus, BA 47 | −48 | 24 | −8 | 0.0193 | ||
|
| ||||||
| Gray matter relative preservation | ||||||
| 1368 | R. Parahippocampal Gyrus, Amygdala | 24 | −4 | −22 | 0.0197 | 9, 11, 17, 19 |
| R. Uncus, BA 28 | 20 | −8 | −30 | 0.0194 | ||
| R. Parahippocampal Gyrus, BA 34 | 22 | −14 | −24 | 0.0164 | ||
| 1040 | L. Thalamus, Ventral Posterior Medial Nucleus | −16 | −20 | 6 | 0.0297 | 5, 10, 11, 17 |
| 1000 | L. Parahippocampal Gyrus, Amygdala | −26 | −4 | −22 | 0.0205 | 9, 17, 19 |
| 992 | R. Thalamus, Ventral Posterior Medial Nucleus | 18 | −20 | 6 | 0.0282 | 5, 10, 11, 17 |
| 696 | R. Cingulate Gyrus, BA 24 | 4 | 10 | 32 | 0.0160 | 1, 10, 19 |
| 336 | L. Cingulate Gyrus, BA 24 | −6 | −14 | 36 | 0.0163 | 1, 5 |
The clusters in bold represent the clusters which overlap with executive function related hyper-activations in the old individuals. Contributed studies # refers to the study # in Table 2. L, left; R, right; BA, Brodmann's Area.