Table 2.
Effect of cisplatin and combination of cisplatin with telmisartan on hemodynamic parameters.
| Parameters | CON | COC | COCT | ORN | ORC | ORCT |
|---|---|---|---|---|---|---|
| Systolic blood pressure (mmHg) | 154.15±10.19 | 176.84±6.13 | 140.69±0.032 | 177.74±6.52 | 164.03±2.77 | 139.48±5.94# |
| Diastolic blood pressure (mmHg) | 136.95±7.66 | 145.16±1.81 | 123.95±1.14 | 147.37±2.81* | 135.40±1.33 | 124.41±1.46# |
| Heart rate (beats per minute) | 251.95±7.35 | 247.68±1.93 | 238.50±3.01 | 254.89±5.25 | 227.54±5.60 | 223.71±3.08 |
*Significantly different from control group (P < 0.05).
#Significantly different from cancer control group (P < 0.05).
CON: normal control.
COC: control treated with cisplatin (0.23 mg/kg).
COCT: control treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).
ORN: oral cancer control.
ORC: oral cancer treated with cisplatin (0.23 mg/kg).
ORCT: oral cancer treated with cisplatin (0.23 mg/kg) + telmisartan (5 mg/kg/day).