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. 2013 Dec 5;2013:279829. doi: 10.1155/2013/279829

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Copyright © 2013 Dorothy M. Tappenden et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

TCDD treatment influences Mrpl40 mitochondrial localization. (a) Cellular fractionation was performed on AHR in wild type Hepa1c1c7 cells. Fractions from cells exposed to TCDD for 6 hours were probed with antibodies specific to MRPL40, lactate dehydrogenase (LDH), and cytochrome c oxidase subunit 4 (COXIV). The results demonstrate a decreased level of mitochondrial localized Mrpl40 following TCDD exposure. (b) Similar cellular fractionations were next performed on AHR null Hepac12 cells. No decrease in Mrpl40 was observed after exposure to TCDD for 6 hours. LDH was used as the cytosolic fraction control protein and COXIV was used as the purified mitochondrial fraction control protein.