Table 1.
Characteristics of liver transplant recipients at the University of Michigan Health System from June 2002 to July 2008 with preoperative computed tomography scans stratified by total psoas area tertiles (N = 207)
| Characteristic | Tertile 1 (n= 69) | Tertile 2 (n = 69) | Tertile 3 (n = 69) | p-value |
|---|---|---|---|---|
| Age at transplant (y, mean ± SD) | 52.0 ± 9.8 | 52.0 ± 10.2 | 51.1 ± 9.6 | 0.82 |
| TPA, male (mm2, mean ± SD) | 1499.2 ± 309.9 | 2224.8 ± 157.8 | 2915.7 ± 381.5 | <0.01 |
| TPA, female (mm2, mean ± SD) | 954.3 ± 225.3 | 1423.1 ± 120.5 | 1978.8 ± 282.0 | <0.01 |
| Race (n, %) | ||||
| White | 53 (76.8) | 61 (88.4) | 54 (78.3) | 0.17 |
| African American | 5 (7.2) | 7 (10.1) | 11 (15.9) | 0.30 |
| Preoperative BMI (mean ± SD) | 26.5 ± 5.6 | 27.5 ± 6.4 | 29.3 ± 6.3 | 0.03 |
| Indications for Transplantation* (n, %) | ||||
| Hepatitis C virus | 22 (31.9) | 19 (27.5) | 13 (18.8) | 0.21 |
| Hepatitis B virus | 2 (2.9) | 2 (2.9) | 5 (7.3) | 0.35 |
| Hepatocellular carcinoma | 10 (14.5) | 16 (23.2) | 26 (37.7) | 0.01 |
| Alcoholic cirrhosis | 11 (15.6) | 11 (15.6) | 8 (11.6) | 0.70 |
| Primary sclerosing cholangitis | 6 (8.7) | 5 (7.3) | 10 (14.5) | 0.33 |
| Primary biliary cirrhosis | 6 (8.7) | 4 (5.8) | 5 (7.3) | 0.81 |
| Autoimmune hepatitis | 4 (5.8) | 3 (4.4) | 4 (5.8) | 0.91 |
| Nonalcoholic steatohepatitis | 2 (2.9) | 3 (4.4) | 3 (4.4) | 0.88 |
| Fulminant hepatitis failure | 1 (1.5) | 2 (2.9) | 1 (1.5) | 0.78 |
| Alpha-1 antitrypsin deficiency | 1 (1.5) | 2 (2.9) | 0 | 0.36 |
| Wilson’s disease | 0 | 1 (1.5) | 1 (1.5) | 0.60 |
| Other | 9 (13.0) | 6 (8.7) | 4 (5.8) | 0.33 |
| Need for pre-transplant dialysis | 6 (8.7) | 1 (1.5) | 3 (4.4) | 0.13 |
| Preoperative lab values (mean ± SD) | ||||
| MELD score | 22.7 ± 7.9 | 18.7 ± 8.2 | 18.0 ± 6.2 | <0.01 |
| INR | 1.6 ± 0.7 | 1.5 ± 1.0 | 1.5 ± 0.4 | 0.15 |
| Creatinine (mg/dL) | 1.9 ±1.3 | 1.3 ± 0.9 | 1.2 ± 0.7 | <0.01 |
| Total bilirubin (mg/dL) | 4.2 | 4.0 | 3.2 | 0.44 |
| Donor age (years, mean ± SD) | 42.2 ± 18.0 | 36.6 ± 17.2 | 39.7 ± 15.6 | 0.17 |
*
Numbers reported as total number of diagnoses.
49 patients had more than one indication for transplant. Hepatitis C infected patients are divided by the presence or absence of hepatocellular carcinoma (HCC)
TPA: Total Psoas Area measured at the 4th lumbar vertebrae; BMI: body mass index; MELD: model for end stage liver disease; INR: International normalized ratio