Development of the DR-initiated, caspase-executed paradigm on T cell death [14,15,30,31], and the tumor counterattack hypothesis [95].
Caspase-independent death in T cell [11,96].
Involvement of mitochondria in cell death pathways [32–34].
Recent studies supporting the existence of a DR-independent, caspase-independent, mitochondria-centric death pathway in AICD of human anti-tumor T cells [9,10].
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