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. Author manuscript; available in PMC: 2013 Dec 22.
Published in final edited form as: Vaccine. 2010 May 6;28(29):10.1016/j.vaccine.2010.04.074. doi: 10.1016/j.vaccine.2010.04.074

Table-2.

AICD In T Cells: Death Receptor (DR)-Driven, Caspase Executed Vs Caspase-Independent Pathways.

  • Development of the DR-initiated, caspase-executed paradigm on T cell death [14,15,30,31], and the tumor counterattack hypothesis [95].

  • Caspase-independent death in T cell [11,96].

  • Involvement of mitochondria in cell death pathways [32–34].

  • Recent studies supporting the existence of a DR-independent, caspase-independent, mitochondria-centric death pathway in AICD of human anti-tumor T cells [9,10].