Table 1.

Estimated model parameter values for GR kinetics obtained from different species/sources.

	Rat liver [27]		Mouse liver [28]		Erythrocytes [34]		Bovine liver [33]		P. blakesleeanus[30]
Parameter	Value	Sensitivity	Value	Sensitivity	Value	Sensitivity	Value	Sensitivity	Value	Sensitivity
klf (μM-1 min-1)	3.4×103	0.34	2.8×103	0.15	3.3×103	0.25	9.9×102	0.41	2.3×103	0.26
klr (min-1)	1.5×102	4.3×10-3	1.5×102	1×10-6	2.5×105	0.04	6.5×104	0.05	6.4×104	0.07
k2f (min-1)	1.1×106	0.03	1.9×107	0.03	6.7×107	0.024	6.7×107	0.041	6.7×107	0.1
k2r (μM-1 min-1)	1.3×104	0.035	-	-	9.1×104	0.058	3.4×104	0.06	4.6×106	0.22
k3f (min-1)	7.8×104	0.31	3.4×104	0.54	2.7×104	0.54	1.3×105	0.24	1.0×105	0.32
k4f (min-1)	5.6×104	0.07	3.2×104	0.28	1.7×105	0.054	8.1×104	0.20	8.0×104	0.22
k4r (μM-1 min-1)	-	-	-	-	-	-	10.2	0.06	1.32	0.24
k5f (min-1)	9.5×104	0.24	2.1×105	0.03	5.8×104	0.2	2.2×105	0.11	1.2×105	0.1
Kp (μM)	93	0.24	-	-	237	0.22	50	0.42	152	0.31
KB (μM)	56	0.39	88	0.3	54	0.25	22	0.16	25.7	0.22
KIA (μM)	1.0×107	4×10-7	436	0.06	8.0×106	8×10-7	8×106	1×10-6	82	0.08
α	2.83	0.26	1.78	0.27	1.2	0.20	9.8	0.13	2.7	0.2
KH (μM)	0.1a		0.1a		0.1a		0.1a		0.03	0.029
Keq,GRb	1.6×108		9.2×107		1.6×108		1.2×108		2.1×108

^aParameter fixed based on the pK information from [34].

^bNot an adjustable parameter and calculated based on thermodynamic data. ‘^-’These parameters do not play a role in fitting the experimental data for the respective data set and can be fixed based on the other data sets.