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. Author manuscript; available in PMC: 2014 Dec 7.
Published in final edited form as: J Theor Biol. 2013 Aug 21;338:10.1016/j.jtbi.2013.08.011. doi: 10.1016/j.jtbi.2013.08.011

Fig. 1. Transition between steady states in chronic inflammation.

Fig. 1

A gradually increasing bacterial load (LPS) produces an abrupt transition from a gradually-changing intermediate state to a heightened persistent inflammatory state. This transition is shown in the pro-inflammatory signaling variable (P), but it is equally apparent in other components of the system.