Figure 2.

DS2 enhances the tonic conductance recorded from dLGN thalamic relay neurons but does not alter IPSC properties. (A) Scatter-plots of individual IPSC peak amplitude (pA) and 10–90% rise-time (ms) recorded from a dLGN thalamic neuron (V_H −70 mV) in the absence (control) and presence of 10 μM DS2. (B) Time course of the average holding current calculated every 1 s from consecutive 100 ms current epochs during the application of 10 μM DS2 and 100 μM gabazine. (C) Scatter plot of the average tonic conductance and average sIPSC decay before and after DS2 application. The data for individual cells are linked by dashed lines and arrows to illustrate the consistent increase in the tonic conductance that took place with no consistent change in the estimated IPSC decay. Superimposed on this plot are the average values across all cells (mean ± SEM, n = 4).