Figure 1. Expression of a2V is decreased in PGN+poly(I:C) induced preterm labor.
Panels A, B and C show expression of a2V mRNA in uterus, placenta and fetal membrane recovered from control and PGN+poly(I:C) treated groups. Panel D shows the distribution of a2V protein, panels E and F show the immunostaining index score [(ISIS) = Stained area score (SAS) X Immunostaining intensity score (IIS)] of a2V in uterus and placenta recovered from control and PGN+poly(I:C) treated groups. Panel G shows the level of cleaved N-terminus domain of a2V i.e., a2NTD in uterus (lane 1) control and (lane 2) PGN+poly(I:C) treatment; and in placenta (lane 3) control and (lane 4) PGN+poly(I:C) treatment. N=6–11 each group. Six sections per animal were analyzed. Error bars=±SEM. *P≤0.05, **P≤0.01 Significant difference vs respective control. Original magnification: 400X.