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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Immunol. 2013 Oct 25;191(11):10.4049/jimmunol.1301604. doi: 10.4049/jimmunol.1301604

Figure 5. PGN+poly(I:C) induces apoptosis in the placenta via the extrinsic pathway.

Figure 5

Immunolocalization of Bax, panel A and B; Bcl2, panel C and D; active caspase-9, panel E and F; active caspase-8, panel G and H; active caspase-3, panel I and J in placenta recovered from the control and PGN+poly(I:C) treated groups. Panel K and L are merged images (DAPI nuclear stain (blue), merged with FITC (stain for activated caspase-3)). Panels M, N, O and P show the immunostaining index score (ISIS) of Bax, Bcl2, active caspase-9 and active caspase-8 in placentas recovered from control and PGN+poly(I:C) treated groups. N=6 each group and six sections per animal were analyzed. Error bars= ±SEM. *P≤0.05 Significant difference vs respective control. Original magnification: 400X.