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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Cancer Res. 2013 Sep 26;73(22):10.1158/0008-5472.CAN-13-1002. doi: 10.1158/0008-5472.CAN-13-1002

Figure 1.

Figure 1

Co-expression and prognostic role of CIP2A and Chk1 in human malignancies. A, Paraffin block sections of gastric cancer specimens from patients (n=223) were subjected to IHC analysis using antibodies against Chk1 and Claspin (CLSPN). B, Statistical analysis of association between Chk1 and Claspin immunopositivity in gastric cancer specimens. C, Immunohistochemical analysis of Chk1, Claspin and CIP2A protein expression in gastric cancer specimens (n=223). D, Statistical analysis of association between Chk1, Claspin and CIP2A immunopositivity in gastric cancer specimens. E, Statistically significant correlation between Chk1 and CIP2A mRNA expression in human neuroblastomas. F, Kaplan-Meier curves demonstrating a significant decrease in overall survival of neuroblastoma patients with high Chk1 and CIP2A mRNA expression. G, Expression of CIP2A mRNA in MYCN amplification positive and negative neuroblastoma patients. H, Co-relation coefficient between Chk1 and CIP2A expression in MYCN amplification positive and negative neuroblastoma patients.