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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Cancer Res. 2013 Sep 26;73(22):10.1158/0008-5472.CAN-13-1002. doi: 10.1158/0008-5472.CAN-13-1002

Figure 4.

Figure 4

Inhibition of CIP2A expression defines cellular response to Chk1 inhibition. A-E, Exogenous CIP2A expression (CIP2A Flag) prevents inhibition of CIP2A protein expression, and cell viability in Chk1 siRNA transfected AGS (A and B), MKN-28 (C and D) and MDA-MB231 (E) cells. F, Exogenous CIP2A expression (CIP2A Flag) prevents inhibition of colony growth of Chk1 and Claspin siRNA transfected AGS cells. G, Effect of small molecule inhibitor of Chk1, SB218078 (1uM for 48h) on CIP2A expression in CIP2A-dependent AGS and CIP2A-independent PNT2 cells. H, Effect of small molecule inhibitor of Chk1, SB218078 (1uM for 48h) on cell viability of AGS and PNT2 cells. Shown are mean values + S.D., from three to four independent experiments (student's t-test).