Figure 2.

Cleavage sites of NEP within the Aβ-sequence and positions of FAD mutations. Within the Aβ sequence there are several cleavage sites for neprilysin (NEP), the cleavage positions of α-, β-, and γ-secretase are also indicated. Some of the pathological point mutations within the Aβ sequence are reported to result in a higher resistance of the peptide to NEP-catalyzed proteolysis (highlighted in red), other known mutation sites are shown in orange. The amino acid numbers are referring to the APP695 isoform.