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SMN-reporter mini-genes. The top diagram illustrates the changes made to the new reporter (see text). The asterisk denotes a restriction site included during cloning that is unique to the SMN reporter gene. These reporters produce an SMN-luciferase fusion protein when exon 7 is included (third diagram) but not when exon 7 is skipped (bottom diagram); ~90% of mRNA from the SMN2-reporter mini-gene skips exon 7.
