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. Author manuscript; available in PMC: 2013 Dec 23.
Published in final edited form as: Gynecol Oncol. 2010 Jan;116(1):10.1016/j.ygyno.2009.09.016. doi: 10.1016/j.ygyno.2009.09.016

Figure 2.

Figure 2

Definitions of PFS

First PFS (pre-protocol intervention) was measured as the time interval from the start of first-line therapy to the date of first relapse (PFS 1). Second PFS was measured as the interval from the start of second-line therapy to the date of the second relapse (PFS 2). Third PFS was measured as the interval from the start of third-line therapy to the date of third relapse (PFS 3). Since there were no strict eligibility entry criteria limiting the duration of second-line chemotherapy, we also explored calculating PFS 2 from the end of chemotherapy to relapse in order to avoid bias in prolonging PFS 2 due to unequal number of cycles on second-line chemotherapy (PFS end). Finally, PFS was defined as the time from the protocol start date to progression, or last follow-up for the patients who did not progress (PFS protocol). PFS intervals are reported in months.