. Author manuscript; available in PMC: 2013 Dec 23.

Published in final edited form as: Gynecol Oncol. 2009 Aug 7;115(2):10.1016/j.ygyno.2009.06.038. doi: 10.1016/j.ygyno.2009.06.038

Table 3.

Multivariate Cox proportional hazards model (adjusted for surgeon effect) to estimate the association between different perioperative CA-125 response categories and progression-free survival (PFS)

Parameter	Hazard Ratio (95% CI)	P
Taxane, yes versus no^*	0.70 (0.48-1.03)	0.06
Chemotherapy cycles, ≥6 versus <6^*	1.36 (0.87-2.12)	0.15
Age (5-year increments)	1.004 (0.95-1.07)	0.80
Ascites volume^**	1.09 (1.03-1.14)	<0.001
Histology (serous versus non serous)	1.03 (0.79-1.39)	0.91
Preoperative CA-125^**	1.08 (0.94-1.23)	0.29
Residual disease
Suboptimal versus optimal	1.47 (1.06-2.04)	0.02
Perioperative CA-125 response^***		0.003
Increase versus ≥80% decline	2.49 (1.37-4.52)	0.003
0-49.99% decline versus ≥80% decline	2.20 (1.40-3.47)	<0.001
50-79.99% decline versus ≥80% decline	1.50 (1.08-2.08)	0.01

95% CI, Hazard Ratio Confidence Interval

time-dependent covariate

^**

Logarithmic scale

^***

Trend test