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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Evol Dev. 2013 May;15(3):10.1111/ede.12035. doi: 10.1111/ede.12035

Fig. 5.

Fig. 5

Chemically modulating RA synthesis and signaling shifts the expression of Pitx2, a left-side determinant of asymmetric gut looping. Compared to the domain of Pitx2 expression (purple) revealed by in situ hybridization in Xenopus embryos (A), the Pitx2 domain is shifted posteriorly and ventrally in the Lepidobatrachus embryo (B). C–D: Pitx2 expression is shifted posteriorly and ventrally in Xenopus embryos exposed to DEAB (C), and anteriorly and dorsally in Lepidobatrachus embryos exposed to RA (D). Arrows in A and C indicate the posterior limit of Pitx2 expression; those in B and D indicate the anterior limit.