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. 2013 Dec 1;11(9-10):561–572. doi: 10.1089/adt.2013.548

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Copyright 2013, Mary Ann Liebert, Inc.

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Fig. 7. — Attenuation of DOX-induced heart failure. (A) DOX-treated embryos exhibit cardiac edema and heart failure. (B) Worsening heart failure by A11 and DOX. Arrow points to the additional edema formed in the yolk. Also see (D) for quantitative result. (C) Dosage curve of DOX-induced heart failure in zebrafish embryos. The cardiac assessment was done after 96 hpf. (D) Attenuation of DOX-induced heart failure by NS398, C25, and MEK-I, but not by A11. The data presented are means±SEM of triplicate wells (n=3), and the experiments have been repeated at least thrice. DOX, doxorubicin.