Table 2.
Association between Helicobacter pylori infection and interleukin 1β, interleukin 4, interleukin 8, CD14, tumor necrosis factor-α, tyrosine-protein phosphates non-receptor type 11 single nucleotide polymorphism in Indonesian people n (%)
| Polymorphism | H. pylori (+) n = 33 | H. pylori (-) n = 261 | OR1 | 95%CI1 |
| IL-1β T-31C | ||||
| TT | 8 (24.2) | 59 (22.6) | ref | |
| CC | 8 (24.2) | 73 (28.0) | 0.82 | 0.29-2.32 |
| TC | 17 (51.5) | 129 (49.4) | 1.05 | 0.42-2.59 |
| TC/CC | 25 (75.8) | 202 (77.4) | 0.96 | 0.41-2.26 |
| IL-4 T-33C | ||||
| TT | 15 (45.5) | 128 (49.0) | ref | |
| CC | 2 (6.1) | 19 (7.3) | 0.83 | 0.17-3.99 |
| TC | 16 (48.5) | 114 (43.7) | 1.24 | 0.58-2.64 |
| CC/TC | 18 (54.5) | 133 (51.0) | 1.18 | 0.56-2.45 |
| IL-8 T-251A | ||||
| TT | 14 (42.4) | 98 (37.6) | ref | |
| AA | 8 (24.2) | 49 (18.8) | 1.25 | 0.48-3.27 |
| TA | 11 (33.3) | 114 (43.7) | 0.74 | 0.32-1.72 |
| TA/AA | 19 (57.6) | 163 (62.5) | 0.89 | 0.42-1.88 |
| CD14 C-159T | ||||
| CC | 7 (21.2) | 65 (24.9) | ref | |
| TT | 8 (24.2) | 65 (24.9) | 1.09 | 0.37-3.20 |
| CT | 18 (54.6) | 131 (50.2) | 1.26 | 0.50-3.19 |
| CT/TT | 26 (78.8) | 196 (75.1) | 1.2 | 0.50-2.92 |
| TNF-α T-1031C | ||||
| TT | 11 (33.3) | 120 (46.0) | ref | |
| CC | 6 (18.2) | 36 (13.8) | 1.99 | 0.67-5.89 |
| TC | 16 (48.5) | 105 (40.2) | 1.66 | 0.73-3.76 |
| CC/TC | 22 (66.7) | 141 (54.0) | 1.74 | 0.80-3.76 |
| PTPN11 G/A at intron 3 | ||||
| GG | 17 (51.5) | 151 (57.9) | ref | |
| AA | 1 (3.0) | 17 (6.5) | 0.6 | 0.07-4.86 |
| GA | 15 (45.5) | 93 (35.6) | 1.49 | 0.70-3.15 |
| GA/AA | 16 (48.5) | 110 (42.2) | 1.37 | 0.65-2.85 |
1
Odds rate with CI adjusted for age and sex by logistic regression model. H. pylori: Helicobacter pylori; IL: Interleukin; PTPN11: Tyrosine-protein phosphates non-receptor type 11.